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Replicated Association Study between Tuberculosis and CLCN6, DOK7, HLA-DRA in Korean

Biomedical Science Letters 2020년 26권 3호 p.238 ~ 243
김성수, 박민, 박상정,
소속 상세정보
김성수 ( Kim Sung-Soo ) - Hoseo University College of Life and Health Sciences Department of Biomedical Laboratory Science
박민 ( Park Min ) - Daekyeung University Department of Biomedical Laboratory Science
박상정 ( Park Sang-Jung ) - Hoseo University College of Life and Health Sciences Department of Biomedical Laboratory Science

Abstract


Tuberculosis is a global public health problem and manifests itself as a difference in the genetic susceptibility of the host, along with the properties of Mycobacterium tuberculosis (MTB). The single nucleotide polymorphisms (SNPs) and candidate genes proposed in the Genome-wide association study (GWAS) on tuberculosis in a recently published Chinese population were reported. In this study, we investigated whether the genetic polymorphism of candidate genes related to tuberculosis is reproduced when targeting Koreans. The CLCN6 (rs12404124, rs198391, rs535107), DOK7 (rs1203104, rs1203103) and HLA-DRA (rs1051336) gene polymorphisms showed statistically significant results. In addition, it was also found whether it acts as an expression quantitative trait loci (eQTL) that can influence gene expression. This study confirmed that the genetic polymorphism of the three genes (CLCN6, DOK7, HLA-DRA) affects the development of tuberculosis and will help to understand the genetic specificity of tuberculosis and the interaction between pathogens and hosts.

키워드

Mycobacterium tuberculosis (MTB); CLCN6; DOK7; HLA-DRA; SNP

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