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Disseminated Cryptococcosis Incorrectly Managed: a Case Report

Journal of Mycology and Infection 2019년 24권 1호 p.28 ~ 31
Maleb Adil, Hami Aziza, Lahlou Yassine Ben, Lamrabat Somiya, Rifai Safaa, Rahmani Nawal, Bensalah Mohammed, Frikh Mohammed, Lemnouer Abdelhay, Elouennass Mostafa,
소속 상세정보
 ( Maleb Adil ) - Mohammed VI University Hospital Laboratory of Microbiology
 ( Hami Aziza ) - Jerada Provincial Hospital Center Department of Medical Analysis Laboratory
 ( Lahlou Yassine Ben ) - Mohammed V Military Teaching Hospital Department of Bacteriology
 ( Lamrabat Somiya ) - Mohammed VI University Hospital Laboratory of Microbiology
 ( Rifai Safaa ) - Mohammed VI University Hospital Laboratory of Microbiology
 ( Rahmani Nawal ) - Mohammed VI University Hospital Laboratory of Microbiology
 ( Bensalah Mohammed ) - Mohammed VI University Hospital Laboratory of Microbiology
 ( Frikh Mohammed ) - Mohammed V Military Teaching Hospital Department of Bacteriology
 ( Lemnouer Abdelhay ) - Mohammed V Military Teaching Hospital Department of Bacteriology
 ( Elouennass Mostafa ) - Mohammed V Military Teaching Hospital Department of Bacteriology

Abstract


Disseminated cryptococcosis is a rare fungal infection, which mainly occurs in immunocompromised patients, and the diagnosis is difficult. Therefore, it is less likely to be considered in immunocompetent patients. Here, we present a case of fatal cryptococcal infection of the pleural fluid and ascites in a patient seronegative for HIV. The patient was a 45-year old man who was followed for Crohn’s disease and treated with steroids and an immunosuppressant (azathioprine). The culture of pleural and ascites fluids showed the presence of yeasts colonies identified as Cryptococcus neoformans. Bacteriological examination of the blood culture or cerebrospinal fluid (CSF) was not prescribed. The HIV serology was negative. At the fourth day of treatment, the patient died because of the deterioration of neurological and hepatocellular functions. The main diagnostic problems that led to this fatal outcome were non-suspicion of an at-risk patient, lack of microbiological analysis of the blood or CSF, and inadequate antifungal therapy.

키워드

Ascites; Cryptococcus neoformans; Pleura

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