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A Case of Cutaneous Purpureocillium lilacinum Infection

Journal of Mycology and Infection 2021년 26권 1호 p.8 ~ 12
정의성, 이상경, 이일재, 박진, 윤석권, 김한욱,
소속 상세정보
정의성 ( Jung Eui-Sung ) - Chonbuk National University Medical School Department of Dermatology
이상경 ( Lee Sang-Kyung ) - Chonbuk National University Medical School Department of Dermatology
이일재 ( Lee Il-Jae ) - Chonbuk National University Medical School Department of Dermatology
박진 ( Park Jin ) - Chonbuk National University Medical School Department of Dermatology
윤석권 ( Yun Seok-Kweon ) - Chonbuk National University Medical School Department of Dermatology
김한욱 ( Kim Han-Uk ) - Chonbuk National University Medical School Department of Dermatology

Abstract


Purpureocillium lilacinum (formerly Paecilomyces lilacinus) is a saprophytic fungus found in the soil and decaying vegetation and is rarely pathogenic to humans. To our knowledge, only six cases of cutaneous infection caused by P. lilacinum have been reported in journals published by the Korean Dermatological Association and the Korean Society for Medical Mycology. Here, we report the case of a patient with localized cutaneous infection caused by P. lilacinum. An 84-year-old woman presented with a 2-month history of multiple plaques with surrounding erythematous patches on her left forearm and dorsum of the hand. Histopathological examination showed suppurative inflammation accompanied by fungal elements in the dermis. Furthermore, periodic acid-Schiff and methenamine silver staining showed revealed fungal elements. The sub-cultured fungus of the isolate revealed velvety pink colonies that were yellowish-tan on the reverse side, and lactophenol cotton blue staining showed flask-shaped phialides. The DNA sequence from the colony was identical to that of P. lilacinum. The patient was treated with oral itraconazole (200 mg/d) for 6 weeks that achieved significant improvement in the patient's condition.

키워드

Cutaneous infection; Purpureocillium; lilacinum

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