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Distribution of “molybdenum disulfide/cobalt ferrite” nanocomposite in animal model of breast cancer, following injection via differential infusion flow rates

Journal of Pharmaceutical Investigation 2020년 50권 6호 p.583 ~ 592
Alavijeh Mohammadhossein Shahsavari, Maghsoudpour Adel, Khayat Morteza, Rad Iman, Hatamie Shadie,
소속 상세정보
 ( Alavijeh Mohammadhossein Shahsavari ) - Islamic Azad University Science and Research Branch Department of Mechanical Engineering
 ( Maghsoudpour Adel ) - Islamic Azad University Science and Research Branch Department of Mechanical Engineering
 ( Khayat Morteza ) - Islamic Azad University Science and Research Branch Department of Mechanical Engineering
 ( Rad Iman ) - Stem Cell Technology Research Center
 ( Hatamie Shadie ) - Stem Cell Technology Research Center

Abstract


Purpose: Aims were to investigate pattern of distribution of “molybdenum disulfide/cobalt ferrite” magnetic nanocomposite (MNC), following injection into the BALB/c mice tumor.

Methods: MNCs were characterized by microscopic, spectroscopic and magneto-metric techniques. To have a gland tumor, 4T1 cells injected subcutaneously. After 1 week of tumor growth, MNCs injected to the tumor at different speed rates, and tumor size monitored after magnetic fluid hyperthermia (MFH) by seven days via measurement of tumors’ outer dimensions, histopathology and qRT-PCR assay techniques.

Results: Neither MoS2/CoFe2O4 nor applied alternative magnetic field (AMF) diminished viability of tumor cells. However, when concentration of 200 μg/ml injected by speed rate of 10 μl/min to the tumor in the presence of AMF (f?=?150 kHz, H?=?31.16 mT), significant diminution of tumor size and considerable raise of tumor necrosis observed. At the same time, up-regulation of Bax and p53, and down-regulation of VEGF and Bcl2 was detected.

Conclusion: Uniform distribution of MNC in optimized condition resulted in significant diminution of tumor size after MFH. Besides, injection of MoS2/CoFe2O4 to the tumor left no sign of necrosis or inflammation in the mice liver. These features of MoS2/CoFe2O4 introduce it as a promising candidate for further clinical studies.

키워드

Magnetic nanocomposite (MNC); Breast cancer; Magnetic fluid hyperthermia (MFH); Alternative magnetic field (AMF) and tumor necrosis

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