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Melatonin: A Potent Therapeutic Candidate in Degenerative Neural Damages

Chronobiology in Medicine 2020년 2권 3호 p.85 ~ 95
Khan Zeeshan Ahmad, 홍윤경, 최정현, 이영전, 진윤호,
소속 상세정보
 ( Khan Zeeshan Ahmad ) - Inje University College of Healthcare Medical Science and Engineering Department of Physical Therapy
홍윤경 ( Hong Yun-Kyung ) - Inje University College of Healthcare Medical Science and Engineering Department of Physical Therapy
최정현 ( Choi Jeong-Hyun ) - Inje University College of Healthcare Medical Science and Engineering Department of Physical Therapy
이영전 ( Lee Young-Jeon ) - Korea Research Institute of Bioscience and Biotechnology National Primate Research Center
진윤호 ( Jin Yun-Ho ) - Inje University College of Healthcare Medical Science and Engineering Department of Physical Therapy

Abstract


The hormone of darkness “melatonin” has shown extraordinary potential. Owing to versatile properties which include, but are not limited to, strong antioxidation, anti-inflammatory, anti-apoptotic, and chronotherapeutic action has generated a great deal of interest as a therapeutic drug for various diseases especially neural damage and neurodegenerative diseases. Melatonin has shown to be effective in arresting neurodegeneration in experimental models of Alzheimer’s, Huntington’s, and Parkinson’s disease, subarachnoid hemorrhage, and ischemic stroke. In this article, the authors review the role of melatonin in neural damage and associated diseases. Briefly, we will discuss the function and protective role of melatonin in the central and peripheral nervous systems. Subsequently, an overview of the role of melatonin in endoplasmic reticulum and mitochondria in neural tissues along with possible biological pathways will be addressed. Finally, we will review the action of melatonin on programmed cell death and its probable molecular mechanism.

키워드

Melatonin; Neural damage; Antioxidant; Apoptosis; Therapeutics

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