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Circadian Rhythm of Heart Rate Assessed by Wearable Devices Tends to Correlate with the Circadian Rhythm of Salivary Cortisol Concentration in Healthy Young Adults

Chronobiology in Medicine 2020년 2권 3호 p.109 ~ 114
정승화, Seo Ju-Yeon, 전세현, 조철현, 염지원, 정재권, 이정빈, 이택, 이헌정,
소속 상세정보
정승화 ( Jeong Seung-Hwa ) - Korea University College of Medicine Department of Psychiatry
 ( Seo Ju-Yeon ) - Korea University College of Medicine Department of Psychiatry
전세현 ( Jeon Se-Hyun ) - Korea University College of Medicine Department of Psychiatry
조철현 ( Cho Chul-Hyun ) - Chungnam National University Sejong Hospital Department of Psychiatry
염지원 ( Yeom Ji-Won ) - Korea University College of Medicine Department of Psychiatry
정재권 ( Jeong Jae-Gwon ) - Korea University College of Medicine Department of Psychiatry
이정빈 ( Lee Jung-Been ) - Korea University College of Medicine Department of Psychiatry
이택 ( Lee Taek ) - Sungshin Women’s University College of Knowledge-based Services Engineering Department of Convergence Security Engineering
이헌정 ( Lee Heon-Jeong ) - Korea University College of Medicine Department of Psychiatry

Abstract


Objective: The objective of this study was to determine whether the circadian rhythm of heart rate or step count using wearable devices was related to that of the salivary cortisol levels and to test the possibility that the data from wearable devices could be used as an indicator of circadian rhythm misalignment, which is emerging as a cause of insomnia and mood disorders.

Methods: The heart rate and step count were continuously measured in 12 healthy young adults using wearable wrist devices for 5 days, and saliva was sampled every 4 hours, excluding sleeping time, for a total of 48 hours to measure the circadian rhythm of salivary cortisol concentration. Cortisol concentrations were assessed using the enzyme-linked immunosorbent assay. The cosinor analysis for the three measurements, salivary cortisol concentrations, heart rate, and step count, was used to estimate the circadian rhythm.

Results: The mean values of the acrophase of the cosine-fitted curve of cortisol, heart rate, and step count were 9.06, 15.84, and 19.09, respectively, while those of the amplitude were 7.70, 12.60, and 10.68, respectively. In addition, the mean values of the mesor of the cosine-fitted curve for cortisol, heart rate, and step count were 17.19, 73.55, and 45.45, respectively, and those of robustness were 0.82, 0.56, and 0.18, respectively. There was a possible positive correlation between the acrophase of the cosine-fitted curve of salivary cortisol and that of heart rate (r=0.55, p=0.064). However, there was no correlation between the acrophase of the cosine-fitted curve of salivary cortisol and that of step count (r=-0.2, p=0.533).

Conclusion: The findings suggest that the heart rate measured using the wearable activity tracker was a relatively reliable biomarker of circadian rhythm.

키워드

Circadian rhythm; Cortisol; Heart rate; Wearable activity tracker

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