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Association between Depression, Daytime Sleepiness, and Thyroid Function in Patients with Thyroid Hormone Replacement Therapy

Chronobiology in Medicine 2020년 2권 3호 p.129 ~ 133
오진우, 이소진, 김봉조, 이철순, 차보석, 이동윤, 서지영, 이영지, 이재헌, 이윤정, 강명희, 김수경,
소속 상세정보
오진우 ( Oh Jin-Woo ) - Gyeongsang National University Hospital Department of Psychiatry
이소진 ( Lee So-Jin ) - Gyeongsang National University Hospital Department of Psychiatry
김봉조 ( Kim Bong-Jo ) - Gyeongsang National University Hospital Department of Psychiatry
이철순 ( Lee Cheol-Soon ) - Gyeongsang National University College of Medicine Department of Psychiatry
차보석 ( Cha Bo-Seok ) - Gyeongsang National University Hospital Department of Psychiatry
이동윤 ( Lee Dong-Yun ) - Gyeongsang National University Changwon Hospital Department of Psychiatry
서지영 ( Seo Ji-Yeong ) - Gyeongsang National University Changwon Hospital Department of Psychiatry
이영지 ( Lee Young-Ji ) - Gyeongsang National University Changwon Hospital Department of Psychiatry
이재헌 ( Lee Jae-Hon ) - Gyeongsang National University Hospital Department of Psychiatry
이윤정 ( Lee Youn-Jung ) - Gyeongsang National University Hospital Department of Psychiatry
강명희 ( Kang Myung-Hee ) - Gyeongsang National University Changwon Hospital Department of Internal Medicine
김수경 ( Kim Soo-Kyoung ) - Gyeongsang National University Hospital Department of Internal Medicine

Abstract


Objective: Thyroid disease may be associated with various psychiatric disorders, such as mild depression and anxiety. Here, we examined the association between thyroid hormone levels and depression and excessive daytime sleepiness (EDS).

Methods: Participants were patients who visited Gyeongsang National University Hospital for thyroid hormone replacement therapy due to chronic autoimmune thyroiditis or thyroidectomy after diagnosis of thyroid cancer between October 2012 and May 2015. Thyroid function was measured in all patients, who were also evaluated for depression, anxiety, daytime sleepiness, and resilience using the Hospital Anxiety and Depression Scale, Epworth Sleepiness Scale, and Connor-Davidson Resilience Scale.

Results: The patient group consisted of 39 cases of primary hypothyroidism due to chronic autoimmune thyroiditis, especially Hashimoto’s thyroiditis, and 57 cases due to total thyroidectomy after thyroid cancer. The mean ages for the participants were 52.32±5.99 years. In patients with hypothyroidism due to chronic autoimmune thyroiditis or thyroid cancer, triiodothyronine (T3) (β=0.291, p=0.013) was associated with depression. Both T3 (β=-0.351, p=0.003) and free thyroxine (β=-0.346, p= 0.008) were associated with EDS.

Conclusion: We found that depression and EDS may be associated with T3 levels in patients with hypothyroidism receiving thyroid hormone replacement therapy. Therefore, we suggest that there may be a need to consider T3 levels in patients with thyroid hormone replacement therapy who complain of depression or EDS.

키워드

Depression; Anxiety; Psychological resilience; Epworth Sleepiness Scale; Hypothyroidism

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