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Effect of dexamethasone gargle, intravenous dexamethasone, and their combination on postoperative sore throat: a randomized controlled trial

Anesthesia and Pain Medicine 2020년 15권 4호 p.441 ~ 450
기승희, 명인욱, 정순호, 임세훈, 조광래, 김명훈, 한용재, 오민경, 박요한, 김광희, 이정한,
소속 상세정보
기승희 ( Ki Seung-Hee ) - Inje University College of Medicine Department of Anesthesiology and Pain Medicine
명인욱 ( Myoung In-Wook ) - Inje University College of Medicine Department of Anesthesiology and Pain Medicine
정순호 ( Cheong Soon-Ho ) - Inje University College of Medicine Department of Anesthesiology and Pain Medicine
임세훈 ( Lim Se-Hun ) - Inje University College of Medicine Department of Anesthesiology and Pain Medicine
조광래 ( Cho Kwang-Rae ) - Inje University College of Medicine Department of Anesthesiology and Pain Medicine
김명훈 ( Kim Myoung-Hun ) - Inje University College of Medicine Department of Anesthesiology and Pain Medicine
한용재 ( Han Yong-Jae ) - Inje University College of Medicine Department of Anesthesiology and Pain Medicine
오민경 ( Oh Min-Kyung ) - Inje University College of Medicine Department of Pharmacology
박요한 ( Park Yo-Han ) - Inje University College of Medicine Inje University Busan Paik Hospital Department of Surgery
김광희 ( Kim Kwang-Hee ) - Inje University College of Medicine Inje University Busan Paik Hospital Department of Surgery
이정한 ( Lee Jeong-Han ) - Inje University College of Medicine Department of Anesthesiology and Pain Medicine

Abstract


Background: Postoperative sore throat (POST) is a complication that decreases patient satisfaction and increases postoperative complaints. The present study was conducted to investigate effects of gargling with dexamethasone, intravenous dexamethasone injection and the combination of the two on the incidence and severity of POST.

Methods: Study participants were 96 patients who had undergone laparoscopic cholecystectomy, randomly allocated into three groups. Group G gargled with 0.05% dexamethasone solution and were infused intravenous 0.9% normal saline before general anesthesia; group I gargled with 0.9% normal saline and were infused intravenous 0.1 mg/kg dexamethasone; group GI gargled with 0.05% dexamethasone solution and were infused intravenous 0.1 mg/kg dexamethasone. The incidence and severity of POST, hoarseness and cough were evaluated and recorded at 1, 6, and 24 h after the surgery.

Results: There were no significant differences in the total incidence of POST up to 24 postoperative hours among Group G, Group I and Group GI (P = 0.367, Group G incidence = 34.38%, [95% confidence interval, 95% CI = 17.92-50.83], Group I incidence = 18.75%, [95% CI = 5.23-32.27], Group GI incidence = 28.13%, [95% CI = 12.55-43.70]). The other outcomes were comparable among the groups.

Conclusions: In patients who had undergone laparoscopic cholecystectomy, gargling with 0.05% dexamethasone solution demonstrated the same POST prevention effect as intravenous injection of 0.1 mg/kg dexamethasone. The incidence and severity of POST were not significantly different between the combination of gargling with 0.05% dexamethasone solution and intravenous injection of 0.1 mg/kg dexamethasone and use of each of the preventive methods alone.

키워드

Dexamethasone; Endotracheal intubation; Laparoscopic cholecystectomy; Mouth wash; Postoperative complication; Sore throat

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