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Phenolic-Rich Extract from Almond (Prunus dulcis) Hulls Improves Lipid Metabolism in Triton WR-1339 and High-Fat Diet-Induced Hyperlipidemic Mice and Prevents Lipoprotein Oxidation: A Comparison with Fenofibrate and Butylated Hydroxyanisole

Preventive Nutrition and Food Science 2020년 25권 3호 p.254 ~ 262
Harnafi Mohamed, Bekkouch Oussama, Touiss Ilham, Khatib Saloua, Mokhtari Imane, Milenkovic Dragan, Harnafi Hicham, Amrani Souliman,
소속 상세정보
 ( Harnafi Mohamed ) - University Mohammed I Faculty of Sciences Department of Biology
 ( Bekkouch Oussama ) - University Mohammed I Faculty of Sciences Department of Biology
 ( Touiss Ilham ) - University Mohammed I Faculty of Sciences Department of Biology
 ( Khatib Saloua ) - University Mohammed I Faculty of Sciences Department of Biology
 ( Mokhtari Imane ) - University Mohammed I Faculty of Sciences Department of Biology
 ( Milenkovic Dragan ) - INRAE Unit of Human Nutrition
 ( Harnafi Hicham ) - University Mohammed I Faculty of Sciences Department of Biology
 ( Amrani Souliman ) - University Mohammed I Faculty of Sciences Department of Biology

Abstract


Hyperlipidemia and oxidative stress are risk factors for atherosclerosis. In this study, we investigated the hypolipidemic and anti-lipoprotein oxidation activities of polyphenol-rich extracts from almond hulls using Triton WR-1339 and high-fat diet-induced hyperlipemic mice as experimental models. We demonstrated that the almond hull extract significantly reduced total cholesterol, triglycerides and low-density lipoprotein-related plasma cholesterol (LDL-C) in the two experimental models of hyperlipidemia, but significantly increased high-density lipoprotein-related plasma cholesterol (HDL-C). Another beneficial effect of the extract was its ability to reduce the atherogenic index and LDL-C/HDL-C ratio. However, the extract exhibited effective antiradical activity against 2,2-diphenyl-1-picrylhydrazyl and significantly protected lipoprotein-rich plasma from mice against oxidation induced by copper ion. The extract contains 342.63±3.44 mg/g total phenolics, 144.67±6.83 mg/g tannins, and 20.66±0.92 mg/g flavonoids. These finding indicate that almond hulls contain polar products able to lower plasma lipid concentrations and which might be beneficial for the treatment of hyperlipidemia and prevention of atherosclerosis.

키워드

almond hulls; anti-lipoprotein oxidation; hypolipidemia; mice

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