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Changes in the hypothalamic gonadotropin-releasing hormone gene expression and the pituitary luteinizing hormone immunoreactivity in male rats: Comparison of clozapine with typical antipsychotics

Animal Cells and Systems 2000년 4권 2호 p.173 ~ 179
김명옥, 고필옥, 김진현, 정기명, 강상수, 최완성,
소속 상세정보
김명옥 ( Kim Myeong-Ok ) - Gyeongsang National University College of Natural Sciences Department of Biology
고필옥 ( Koh Phil-Ok ) - Gyeongsang National University College of Natural Sciences Department of Biology
김진현 ( Kim Jin-Hyun ) - Gyeongsang National University College of Medicine Department of Anatomy
정기명 ( Chung Ki-Myung ) - Gyeongsang National University College of Medicine Department of Anatomy
강상수 ( Kang Sang-Soo ) - Gyeongsang National University College of Medicine Department of Anatomy
최완성 ( Choi Wan-Sung ) - Gyeongsang National University College of Medicine Department of Anatomy

Abstract


Evidence suggested that atypical antipsychotics (APs) such as clozapine show less side effects than those of typical APs such as haloperidol and sulpiride. However, little is known about chronic effects of these drugs on changes in gonadotropin releasing hormone (GnRH) mRNA expression and luteinizing hormone (LH) immunoreactivity. Male rats were divided into water?, haloperidol?, sulpiride?, and clozapine?treated groups, and these drugs were administered orally for 4 weeks. The changes in the expression of GnRH mRNA and the LH immunoreactivity were determined in the hypothalamus and pituitary, respectively, using in situ hybridization and immun?ohistochemistry. GnRH mRNAs were clearly expressed in the water?treated control rats. This was significantly reduced by the chronic treatments with the typical APs, especially with haioperidoi, but not with atypical APs clozapine. Likewise, LH immunoreactivity was clearly stained in the control group. While its immunoreativity was significantly reduced by the chronic APs treatments, clozapine treatment showed only slight attenuation. The results show that the atypicaj APs clozapine has less side effects in the gonadal function than the typical APs haloperidol and the suipiride. These results suggest that clozapine is a safer drug than the typical APs, at least in the reproductive system.

키워드

Antipsychotics; GnRH; LH; In situ hybridization; Hypothalamus; Pituitary

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