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Isolation of Candidate Nek2@iterating Protein Genes (NIPs)

Animal Cells and Systems 2002년 6권 2호 p.181 ~ 185
유재칠, 장승기, 이건수,
소속 상세정보
유재칠 ( Yoo Jae-Cheal ) - Seoul National University School of Biological Sciences
장승기 ( Jang Sung-Key ) - Pohang University of Science and Technology Department of Life Science
이건수 ( Rhee Kun-Soo ) - Seoul National University School of Biological Sciences

Abstract


Nek2 is a mammalian protein kinase that is structurally homologous to NEMA, a mitotic regulator in Aspergillus nidulans. We recently observed that the Nek2 protein was localized in multiple sites within a cell in a cell cycle stage?specific manner. This suggests that Nek2 is involved in diverse cellular functions during the cell cycle progression. To have a better understanding on cellular functions in which Nek2 participates, we carried out yeast two?hybrid screening and isolated six candidate clones whose products interact with Nek2. Most of Nek2?interacting proteins (NIPs) appear cytoplasmic, suggesting that Nek2 is involved in cellular functions in cytoplasm. Further experiments are under progress to confirm their interactions with Nek2 and to understand their biological significance.

키워드

Nek2; Cell cyclel Yeast two-hybrid screening

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