잠시만 기다려 주세요. 로딩중입니다.

Genetic polymorphism of vascular endothelial growth factor (VEGF C936T) in the Korean population

Animal Cells and Systems 2003년 7권 3호 p.261 ~ 264
김진경, 오도연, 곽선영, 한진희, 정영선, 김남근,
소속 상세정보
김진경 ( Kim Jin-Kyeoung ) - Pochon CHA University Graduate School of Life Science and Biotechnology
오도연 ( Oh Do-Yeun ) - Pochon CHA University Institute for Clinical Research
곽선영 ( Kwak Sun-Young ) - Pochon CHA University Institute for Clinical Research
한진희 ( Han Jin-Hee ) - Pochon CHA University Institute for Clinical Research
정영선 ( Chung Young-Sun ) - Pochon CHA University College of Medicine Department of Neurosurgery
김남근 ( Kim Nam-Keun ) - Pochon CHA University Institute for Clinical Research

Abstract


Vascular endothelial growth factor (VEGF) is a potent regulator of normal and abnormal angiogenesis. Recent literature suggests that VEGF has several activities that may amplify acute inflammation reactions. Dysregulated VEGF expression has been implicated as a major contributor to the development of a number of common disease pathologies. One of common mutations in the 3'?untranslated region of the VEGF gene, a C?T exchange at nucleotide position 936, has been found to be significantly associated with VEGF expression levels in the plasma from a previous Austrian study. The frequency of this mutation could be important genetic information regarding tumor growth and angiogenesis related diseases. The aim of this study was to investigate the frequency distribution of this mutation in general Korean population. We examined the statistical data from 207 healthy Korean subjects. Observed numbers (%) of 936T were 28.5 (CT) and 3.9 (TT), respectively. The mutant allele frequency of 936T in Korean subjects was 0.18, which appeared somewhat higher than that in Austrian subjects.

키워드

VEGF; Polymorphism; Korean population; RFLP

원문 및 링크아웃 정보

등재저널 정보