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Levamisole enhances the natural cytotoxic cell activity of Japanese flounder (paralichthys olivaceus) head kidney leukocytes

Animal Cells and Systems 2004년 8권 4호 p.329 ~ 333
최상훈,
소속 상세정보
최상훈 ( Choi Sang-Hoon ) - Kunsan National University College of Ocean Science and Technology Department of Marine Biomedical Science

Abstract


Japanese flounder (Paralichthys olivaceus) head kidney (HK) leukocytes were incubated with 103 to 10?3 ng levamisole/ml for 4, 24 or 48 h and then assayed for their natural cytotoxic activity against xenogeneic tumor cells. This activity was slightly increased after 24 h of incubation. In a second experiment, fish were fed 0, 75, 150 or 300 mg levamisole/kg diet for 10 consecutive days. The fish were then fed a commercial non?supplemented diet and sampled 0,1,2,3,4 or 6 weeks post?administration of levamisole. The cytotoxic activity was found to be increased with increasing levamisole dose and remained greatly enhanced until the end of the experiment. In conclusion, levamisole enhanced flounder natural cytotoxic cell activity both in vitro and in vivo and had a great lasting action when administered by feeding.

키워드

Levamisole; Cytotoxicity; Japanese flounder; (Paralichthys olivaceus)

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