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Isolation of Caenorhabditis elegans Mutants Defective in Chemotaxis toward cAMP

Animal Cells and Systems 2006년 10권 4호 p.237 ~ 241
정진아, 조남정,
소속 상세정보
정진아 ( Jeong Jin-A ) - Chungbuk National University School of Life Sciences
조남정 ( Cho Nam-Jeong ) - Chungbuk National University School of Life Sciences

Abstract


Chemotactic behavior is essential for the survival of animals. However, the mechanism by which animals carry out chemotaxis is poorly understood. To explore the biochemical events underlying chemotaxis, we isolated C. elegans mutants that displayed abnormal chemotactic responses to cAMP, a strong attractant for C. elegans. Based on their responses to other chemoattractants, the mutant animals could be classified into five groups: (1) animals with defective chemotaxis to cAMP only; (2) animals with defective chemotaxis to both cAMP and cGMP; (3) animals with defective chemotaxis to water?soluble attractants; (4) animals with defective chemotaxis to both water?soluble and volatile attractants; and (5) animals with enhanced chemotactic responses. We expect that analyses of these mutants will help understand the molecular mechanisms underlying chemotaxis in C. elegans.

키워드

Chemotaxis; C. elegans; cAMP; animal behavior; mutant

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