Molecular co-evolution of Gonadotropin-releasing hormones and their receptors
성재영, 권혁방,
소속 상세정보
성재영 ( Seong Jae-Young ) - Korea University Graduate School of Medicine
권혁방 ( Kwon Hyuk-Bang ) - Chonnam National University School of Biological Sciences and Technology Hormone Research Center
Abstract
Gonadotropin?releasing hormone (GnRH), synthesized in the hypothalamus, plays a pivotal role in the regulation of vertebrate reproduction. Since molecular isoforms of GnRH and their receptors (GnRHR) have been isolated in a broad range of vertebrate species, GnRH and GnRHR provide an excellent model for understanding the molecular co?evolution of a peptide ligand?receptor pair. Vertebrate species possess multiple forms of GnRH, which have been created through evolutionary mechanisms such as gene/chromosome duplication, gene deletion and modification. Similar to GnRHs, GnRH receptors (GnRHR) have also been diversified evolutionarily. Comparative ligand?receptor interaction studies for non?mammalian and mammalian GnRHRs combined with mutational mapping studies of GnRHRs have aided the identification of domains or motifs responsible for ligand binding and receptor activation. Here we discuss the molecular basis of GnRH?GnRHR co?evolution, particularly the structure?function relationship regarding ligand selectivity and signal transduction of mammalian and non?mammalian GnRHRs.
키워드
GnRH; receptor; G protein-coupled receptors; ligand selectivity; signal transduction; co-evolution
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