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RNA interference in C. elegans: History, application, and perspectives

Animal Cells and Systems 2007년 11권 2호 p.99 ~ 104
민경우, 이준호,
소속 상세정보
민경우 ( Min Kyoeng-Woo ) - Seoul National University School of Biological Sciences
이준호 ( Lee Jun-Ho ) - Seoul National University School of Biological Sciences

Abstract


RNA interference (RNAi) is the phenomenon of gene silencing by double?stranded RNA (dsRNA) at transcriptional and post?transcriptional levels in a sequence?specific manner. Reverse genetic approaches using RNA interference (RNAi) have become a major tool for biological researches since its discovery in the nematode Caenorhabditis elegans. In this review, we overview how the RNAi phenomenon was discovered and how the underlying mechanism has been elucidated. We also describe and discuss how RNAi experiments can be performed and how RNAi can be used for genetic studies.

키워드

C. elegans; RNA interference

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