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The effect of idesolide on hippocampus-dependent recognition memory

Animal Cells and Systems 2008년 12권 1호 p.11 ~ 14
이혜련, 최준혁, 이누리발해, 김승현, 김영중, 강봉균,
소속 상세정보
이혜련 ( Lee Hye-Ryeon ) - Seoul National University College of Natural Sciences Department of Biological Sciences
최준혁 ( Choi Jun-Hyeok ) - Seoul National University College of Natural Sciences Department of Biological Sciences
이누리발해 ( Lee Nuribalhae ) - Seoul National University College of Natural Sciences Department of Biological Sciences
김승현 ( Kim Seung-Hyun ) - Seoul National University College of Pharmacy
김영중 ( Kim Young-Choong ) - Seoul National University College of Pharmacy
강봉균 ( Kaang Bong-Kiun ) - Seoul National University College of Natural Sciences Department of Biological Sciences

Abstract


Finding a way to strengthen human cognitive functions, such as learning and memory, has been of great concern since the moment people realized that these functions can be affected and even altered by certain chemicals. Since then, plenty of endeavors have been made to look for safe ways of improving cognitive performances without adverse side?effects. Unfortunately, most of these efforts have turned out to be unsuccessful until now. In this study, we examine the effect of a natural compound, idesolide, on hippocampus?dependent recognition memory. We demonstrate that idesolide is effective in the enhancement of recognition memory, as measured by a novel object recognition task. Thus, idesolide might serve as a novel therapeutic medication for the treatment of memory?related brain anomalies such as mild cognitive impairment (MCI) and Alzheimer’s disease.

키워드

idesolide; recognition memory; novel object recognition task

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