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A novel Kinesin-like protein, Surhe is associated with dorsalization in the zebrafish embryos

Animal Cells and Systems 2008년 12권 4호 p.219 ~ 230
김은중, 노현주, 허태린, 이창중, 최진희, 이명철,
소속 상세정보
김은중 ( Kim Eun-Joong ) - Seoul National University College of Pharmacy
노현주 ( Ro Hyun-Ju ) - NIH-NICHD-LMG
허태린 ( Huh Tae-Lin ) - Kyungpook National University Department of Genetic Engineering
이창중 ( Lee Chang-Joong ) - Inha University College of Natural Sciences Department of Biology
최진희 ( Choi Jin-Hee ) - University of Seoul College of Urban Sciences School of Environmental Engineering
이명철 ( Rhee Myung-Chull ) - Chungnam National University Department of Biology

Abstract


We are reporting the expression patterns and possible biological functions of a novel Kinesin?like protein, Surhe, in the zebrafish. Homology studies of derived amino acid sequences suggest that Surhe has an amino?terminal kinesin motor domain that is similar to that of the emerging MKLP?1 subfamily [Kim and Endow, 2000] and two coiled?coil domains in a central region. Cellular localization studies in mammalian cells revealed that Surhe protein is located in cytoplasm, suggesting that Surhe may be involved in the intracellular transport. During the developmental process, surhe transcripts are highly expressed in early embryonic stages. Overexpression of the dominant negative form of Surhe significantly down?regulates the dorsalization markers, such as goosecoid, bozozok, and chordin. Taken together, we postulate that Surhe may be involved in dorsalization process as a motor molecule.

키워드

kinesin-like protein; Surhe; dorsal determinant; dorsalization

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