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Characterization of angiogenesis inhibitor effect of green tea seed extract

Animal Cells and Systems 2009년 13권 2호 p.133 ~ 139
황재호, 이성훈, 라성주, 윤호섭, 신진혁, 이진희, 서명진, 강경완, 한경호, 김용주, 고강희, 김선재, 신태선, 오명주, 오석중, 서효진, 김종덕,
소속 상세정보
황재호 ( Hwang Jae-Ho ) - Chonnam National University Eco Marine Bio Center
이성훈 ( Lee Sung-Hoon ) - Chonnam National University Division of Fisheries and Ocean Sciences
라성주 ( Rha Sung-Ju ) - Chonnam National University Eco Marine Bio Center
윤호섭 ( Yoon Ho-Seop ) - Chonnam National University Division of Fisheries and Ocean Sciences
신진혁 ( Shin Jin-Hyuk ) - Chonnam National University Department of Biotechnology
이진희 ( Lee Jin-Hee ) - Chonnam National University Division of Fisheries and Ocean Sciences
서명진 ( Seo Myeong-Jin ) - Chonnam National University Department of Biotechnology
강경완 ( Kang Kyeong-Wan ) - Chonnam National University Division of Fisheries and Ocean Sciences
한경호 ( Han Kyeong-Ho ) - Chonnam National University Division of Fisheries and Ocean Sciences
김용주 ( Kim Yong-Joo ) - Chonnam National University Division of Fisheries and Ocean Sciences
고강희 ( Kho Kang-Hee ) - Chonnam National University Eco Marine Bio Center
김선재 ( Kim Seon-Jae ) - Chonnam National University Eco Marine Bio Center
신태선 ( Shin Tai-Sun ) - Chonnam National University Eco Marine Bio Center
오명주 ( Oh Myung-Joo ) - Chonnam National University Eco Marine Bio Center
오석중 ( Oh Suk-Jung ) - ECOBIO Inc.
서효진 ( Seo Hyo-Jin ) - Chonnam National University Department of Biotechnology
김종덕 ( Kim Jong-Deog ) - Chonnam National University Department of Biotechnology

Abstract


Green tea seed was extracted with absolute ethanol, and the green tea seed extract (GTSE) was subjected to assays for toxicity, antioxidant ability, angiogenesis inhibitory effects and cell adhesion, as well as western blotting, and an in vivo experiment against 4 high?ranking adult cancers in Korea. Our series of experimental data demonstrated that GTSE has an antioxidant ability superior to that of EGCG in the green tea leaf, and also exhibits a profound high tumor growth inhibitory activity on a variety of cancer cell lines, as well as nude mice infected with cancer cells. GTSE was identified as a natural anticancer compound showing excellent angiogenesis inhibition and cancer cell suppression abilities. Our preliminary observations also indicate that GTSE may be another potential source of natural dietary antioxidants and also may be applicable as a novel natural anticancer agent.

키워드

green tea seed extract; anti-cancer; anti-angio-genesis; western blotting; in vivo animal experiment

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