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Differential gene expression by chrysotile in human bronchial epithelial cells

Animal Cells and Systems 2012년 16권 2호 p.95 ~ 103
서유나, 이용진, 이미영,
소속 상세정보
서유나 ( Seo Yoo-Na ) - Soonchunhyang University Department of Medical Biotechnology
이용진 ( Lee Yong-Jin ) - Soonchunhyang University Department of Medicine
이미영 ( Lee Mi-Young ) - Soonchunhyang University Department of Medical Biotechnology

Abstract


Asbestos exposure has been known to contribute to several lung diseases named asbestosis, malignant mesothelioma and lung cancer, but the disease-related molecular and cellular mechanisms are still largely unknown. To examine the effects of asbestos exposure in human bronchial epithelial cells at gene level, the global gene expression profile was analyzed following chrysotile treatment. The microarray results revealed differential gene expression in response to chrysotile treatment. The genes up- and down-regulated by chrysotile were mainly involved in processes including metabolism, signal transduction, transport, development, transcription, immune response, and other functions. The differential gene expression profiles could provide clues that might be used to understand the pathological mechanisms and therapeutic targets involved in chrysotile-related diseases.

키워드

chrysotile; human bronchial epithelial cells; differential gene expression

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