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Calcium and bioenergetics: from endoplasmic reticulum to mitochondria

Animal Cells and Systems 2012년 16권 4호 p.269 ~ 273
이덕규, Michalak Marek,
소속 상세정보
이덕규 ( Lee Duk-Gyu ) - University of Alberta Department of Biochemistry
 ( Michalak Marek ) - University of Alberta Department of Biochemistry

Abstract


Controlling metabolism throughout life is a necessity for living creatures, and perturbation of energy balance elicits disorders such as type-2 diabetes mellitus and cardiovascular disease. Ca2+ plays a key role in regulating energy generation. Ca2+ homeostasis of the endoplasmic reticulum (ER) lumen is maintained through the action of Ca2+ channels and the Ca2+ ATPase pump. Once released from the ER, Ca2+ is taken up by mitochondria where it facilitates energy metabolism. Mitochondrial Ca2+ serves as a key metabolic regulator and determinant of cell fate, necrosis, and/or apoptosis. Here, we focus on Ca2+ transport from the ER to mitochondria, and Ca2+-dependent regulation of mitochondrial energy metabolism.

키워드

Ca2+ homeostasis; receptor; endoplasmic reticulum; mitochondria; energy metabolism

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