Callophyllis japonica extract improves high-fat diet-induced obesity and inhibits adipogenesis in 3T3-L1 cells
강성일, 신혜선, 김효민, 윤선아, 강승우, 고희철, 김세재,
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강성일 ( Kang Seong-Il ) - Jeju National University Department of Biology
신혜선 ( Shin Hye-Sun ) - Jeju National University Department of Biology
김효민 ( Kim Hyo-Min ) - Jeju National University Department of Biology
윤선아 ( Yoon Seon-A ) - Jeju National University Department of Biology
강승우 ( Kang Seung-Woo ) - Jeju National University Department of Biology
고희철 ( Ko Hee-Chul ) - Jeju National University Department of Biology
김세재 ( Kim Se-Jae ) - Jeju National University Department of Biology
Abstract
The anti-obesity potential of an ethanolic extract of the edible red alga Callophyllis japonica extract (CJE) was investigated in mice fed a high-fat diet (HFD). CJE administration into HFD mice revealed suppression of body weight, adipose tissue weight, serum total cholesterol, triglyceride, and glucose levels in a dose-dependent manner. Also, it reduced serum levels of glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, and lactate dehydrogenase, as well as the accumulation of fatty droplets in liver tissue. CJE and its ethyl acetate fraction inhibited adipogenesis in 3T3-L1 adipocytes by down-regulating the adipocyte-specific transcriptional regulators. Taken together, these results suggest that CJE reduces obesity in mice fed an HFD by inhibiting lipid accumulation and adipogenesis in the adipose tissues.
키워드
Callophyllis japonica; high-fat diet-induced obesity; anti-obesity; 3T3-L1 cells
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