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Basal anxiety during an open field test is correlated with individual differences in contextually conditioned fear in mice

Animal Cells and Systems 2013년 17권 3호 p.154 ~ 159
안서희, 장은혜, 최준혁, 이혜련, Bakes Joseph, 공영윤, 강봉균,
소속 상세정보
안서희 ( Ahn Seo-Hee ) - Seoul National University Department of Brain and Cognitive Sciences
장은혜 ( Jang Eun-Hae ) - Seoul National University Department of Brain and Cognitive Sciences
최준혁 ( Choi Jun-Hyeok ) - Seoul National University College of Natural Sciences Department of Biological Sciences
이혜련 ( Lee Hye-Ryeon ) - Seoul National University College of Natural Sciences Department of Biological Sciences
 ( Bakes Joseph ) - Seoul National University Department of Brain and Cognitive Sciences
공영윤 ( Kong Young-Yun ) - Seoul National University College of Natural Sciences Department of Biological Sciences
강봉균 ( Kaang Bong-Kiun ) - Seoul National University Department of Brain and Cognitive Sciences

Abstract


Fear conditioning has been used to study pathogenic mechanisms underlying anxiety disorders. Several studies have shown that humans with anxiety disorders exhibit strong fear responses during the acquisition of conditioned fear. However, there have been no studies investigating whether basal anxiety within the normal range is related to conditioned fear in rodents. We hypothesized that individual differences in conditioned fear are correlated to the basal anxiety level of each individual. To test this hypothesis, we measured the basal anxiety of mice by using the elevated-plus maze (EPM) and open field test (OFT) and correlated these data with contextual freezing during contextual fear conditioning (CFC). Strong correlation was found between the basal anxiety level measured in the OFT and contextual freezing in the CFC. Baseline freezing was also strongly correlated with the contextual freezing level during the retrieval phase of CFC. However, the basal anxiety level measured in the EPM was correlated neither with conditioned fear nor with baseline freezing in the CFC. These results suggest that both basal anxiety in the OFT and baseline freezing are related to contextually conditioned fear.

키워드

basal anxiety; conditioned fear; individual differences; baseline freezing; open field test; elevated-plus maze; contextual fear conditioning

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