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Antiplatelet activities of hyperoside in vitro and in vivo

Animal Cells and Systems 2014년 18권 3호 p.204 ~ 209
구새광, 유하영, Zhou Wei, 나민균, 배종섭,
소속 상세정보
구새광 ( Ku Sae-Kwang ) - Daegu Haany University College of Korean Medicine Department of Anatomy and Histology
유하영 ( Yoo Ha-Young ) - Kyungpook National University College of Pharmacy
 ( Zhou Wei ) - Chungnam National University College of Pharmacy
나민균 ( Na Min-Kyun ) - Chungnam National University College of Pharmacy
배종섭 ( Bae Jong-Sup ) - Kyungpook National University College of Pharmacy

Abstract


Thrombosis and thromboembolic occlusions of major and minor blood vessels are a major complication in various peripheral vascular diseases. Antiplatelet agents, key tools in the treatment of atherothrombosis, therefore became a mainstay medication for a wide range of vascular diseases. Hyperoside, an active compound from the Rhododendron brachycarpum G. Don (Ericaceae), was reported to have antioxidant, anti-hyperglycemic, anticancer, anti-inflammatory, and anti-coagulant activities. However, antiplatelet properties of hyperoside have not been studied. In this study, the antiplatelet activities of hyperoside were measured by thrombin- or collagen-induced platelet aggregation in vitro, adenosine diphosphate-induced platelet aggregation in vivo, and the thrombus formation in vivo. Our data showed that in vitro assays using freshly isolated human platelets, hyperoside showed the inhibition of the thrombin- or collagen-induced platelet aggregation. In accordance with these enhanced in vitro antiplatelet activities, hyperoside showed enhanced anti-thrombotic effects in vivo pulmonary embolism model and arterial thrombosis model. Collectively, these results indicate that hyperoside possesses antiplatelet activities and might offer enhanced anti-thrombotic efficacies without increasing side effects.

키워드

hyperoside; antiplatelet; antithrombotic; aggregation

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