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Role of corticotropin-releasing hormone receptor 1 in the regulation of nociception in mice

Animal Cells and Systems 2014년 18권 5호 p.304 ~ 310
박수현, 최성수, 심윤범, 이진구, 서홍원,
소속 상세정보
박수현 ( Park Soo-Hyun ) - Hallym University College of Medicine Department of Pharmacology
최성수 ( Choi Seong-Soo ) - University of Ulsan College of Medicine Asan Medical Center Department of Anesthesiology and Pain Medicine
심윤범 ( Sim Yun-Beom ) - Hallym University College of Medicine Department of Pharmacology
이진구 ( Lee Jin-Koo ) - Dankook University College of Medicine Department of Pharmacology
서홍원 ( Suh Hong-Won ) - Hallym University College of Medicine Department of Pharmacology

Abstract


Corticotropin-releasing hormone (CRH) is known to be involved in both antinociceptive and nociceptive processing. In the present study, we examined the role of the CRH receptor 1 in the regulation of nociception in mice. First, we found that CRH mRNA level was elevated in the hypothalamus or hippocampus by intraperitoneal (i.p.) injection with 1% acetic acid, intraplantar injection of 5% formalin, or intrathecal (i.t.) injection of substance P (0.7 μg/5 μl). Nociceptive behavior induced by acetic acid, formalin, or substance P were reduced in CRHR1 heterozygous (CRHR1+/?) mice compared to that in C57BL6 (wild type, CRHR1+/+) mice group. Furthermore, administration with CRHR1 antagonists such as CP 154526 (10 mg/kg, i.p.) or α-helical CRF 9-41 (10 μg/5 μl, intracerebroventricular [i.c.v.]) attenuated nociceptive behaviors observed in the substance P and writhing pain models. Our results suggest that CRHR1 might play an important role in the regulation of nociception, especially, toward nociceptive activation rather than producing the antinociception.

키워드

nociception; pain; CRHR1

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