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Essential roles of bile acid receptors FXR and TGR5 as metabolic regulators

Animal Cells and Systems 2014년 18권 6호 p.359 ~ 364
Jacinto Sandra, Fang Sungsoon,
소속 상세정보
 ( Jacinto Sandra ) - Salk Institute for Biological Studies Gene Expression Laboratory
 ( Fang Sungsoon ) - Salk Institute for Biological Studies Gene Expression Laboratory

Abstract


Alterations of bile acid (BA) metabolism in type II diabetes (T2D) have revealed a link between BAs and metabolic homeostasis. The BA receptors farnesoid X receptor (FXR) and G-protein coupled BA receptor 1 (TGR5) both have shown to regulate lipid, glucose, and energy metabolism, rendering them potential therapeutic targets for T2D therapy. Astonishingly, BA signaling is vital as it has known to be a positive factor for beneficial improvements in vertical sleeve gastrectomy surgery, in turn making these BA receptors beneficial tools in therapeutic targets for T2D. These metabolic regulators: FXR and TGR5 are essential modulators in the metabolic system, which affect the human machinery and will be the focus of this review.

키워드

bile acid; FXR; TGR5

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