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Induction of telomere shortening and cellular apoptosis by sodium meta-arsenite in human cancer cell lines

Animal Cells and Systems 2017년 21권 4호 p.241 ~ 254
김윤동, 장시정, 임은지, 하정숙, Shivakumar Sharath Belame, 정계준, 노규진, 전병균,
소속 상세정보
김윤동 ( Kim Yoon-Dong ) - Gyeongsang National University College of Education Department of Biology Education
장시정 ( Jang Si-Jeong ) - Gyeongsang National University College of Veterinary Medicine OBS/Theriogenology and Biotechnology
임은지 ( Lim Eun-Ji ) - Gyeongsang National University College of Education Department of Biology Education
하정숙 ( Ha Jeong-Sook ) - Gyeongsang National University College of Education Department of Biology Education
 ( Shivakumar Sharath Belame ) - Gyeongsang National University College of Veterinary Medicine OBS/Theriogenology and Biotechnology
정계준 ( Jeong Gie-Joon ) - Gyeongsang National University College of Education Department of Biology Education
노규진 ( Rho Gyu-Jin ) - Gyeongsang National University College of Veterinary Medicine OBS/Theriogenology and Biotechnology
전병균 ( Jeon Byeong-Gyun ) - Gyeongsang National University College of Education Department of Biology Education

Abstract


The present study assessed the cytotoxicity of sodium meta-arsenite (SMA) on telomere shortening and cellular apoptosis in human A-549, MDA-MB-231 and U87-MG cancer cell lines. Following 2 weeks of 1?μM SMA treatment, population doubling time (PDT) was significantly (P?

키워드

Human; cancer; sodium meta-arsenite; telomere length; apoptosis

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