Inositol pyrophosphates as multifaceted metabolites in the regulation of mammalian signaling networks
박승주, 이슬기, 박승은, 김세연,
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박승주 ( Park Seung-Ju ) - KAIST Department of Biological Sciences
이슬기 ( Lee Seul-Gi ) - KAIST Department of Biological Sciences
박승은 ( Park Seung-Eun ) - KAIST Department of Biological Sciences
김세연 ( Kim Se-Yun ) - KAIST Department of Biological Sciences
Abstract
Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites with high-energy phosphoanhydride bonds. The formation of PP-IPs is catalyzed by two groups of enzymes, the IP6 kinases and the PPIP5 kinases, which both phosphorylate inositol hexakisphosphate (IP6). In mammals, PP-IPs are implicated in diverse biological phenomena including cellular growth, vesicular trafficking, apoptosis, and metabolic homeostasis. Mechanistically, all the diverse actions of PP-IPs proceed in one of two ways: the PP-IPs modulate the activity of their target proteins either through allosteric binding or protein pyrophosphorylation. In this review, we highlight recent advances in our understanding of the pleiotropic functions of the mammalian PP-IPs and the metabolic enzymes that produce them. We also discuss some future challenges in the exploration of areas where PP-IPs play important but unknown roles in physiology and disease.
키워드
Metabolism; inositol pyrophosphate; IP6K; PPIP5K; cell signaling
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