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Steroidogenic effects of Taraxacum officinale extract on the levels of steroidogenic enzymes in mouse Leydig cells

Animal Cells and Systems 2018년 22권 6호 p.407 ~ 414
정현주, 노유헌, 김민수, 장아라, 이채은, 명순철,
소속 상세정보
정현주 ( Chung Hyun-Joo ) - Chung-Ang University College of Medicine Department of Urology
노유헌 ( Noh Yoo-Hun ) - Chung-Ang University College of Medicine Department of Anatomy and Cell Biology
김민수 ( Kim Min-Su ) - Seoul Medical Center Department of Urology
장아라 ( Jang A-Ra ) - Chung-Ang University College of Medicine Department of Urology
이채은 ( Lee Chae-Eun ) - Chung-Ang University College of Medicine Department of Urology
명순철 ( Myung Soon-Chul ) - Chung-Ang University College of Medicine Department of Urology

Abstract


In this study, we investigated the steroidogenic effect of Taraxacum officinale extract on mouse TM3 Leydig cells, which produce male hormones by increasing the levels of steroidogenic enzymes. Steroidogenic enzymes are involved in the production of testosterone in the testis. To date, the steroidogenic effect of T. officinale has not been reported. Therefore, we examined the steroidogenic effects of T. officinale extract (TOE) on mouse Leydig cells in vitro. Traditionally, plants have been used for the treatment of various kinds of ailments. For many years, some medicinal plants have been used to regulate steroidogenesis or late-onset hypogonadism (LOH). In particular, plants belonging to the genus Taraxacum have anti-inflammatory, anti-nociceptive, anti-oxidant, and anti-cancer properties. In this study, we determined whether the TOE exerts steroidogenic effects by increasing the levels of enzymes associated with steroidogenesis, such as the steroidogenic acute regulatory protein (STAR), CYP11A1, and translocator protein (TSPO) in the mitochondria and CYP17A1 in the smooth endoplasmic reticulum, in mouse Leydig cells. Our results showed that the TOE significantly increased the mRNA and protein levels of steroidogenic enzymes, thereby increasing the testosterone levels in mouse Leydig cells. Thus, our results indicate that the TOE increases the levels of steroidogenic enzymes, and further studies are required to establish the potential of this plant in regulating steroidogenesis and improving LOH.

키워드

Taraxacum officinale extract (TOE); medicinal plant; steroidogenesis; late-onset hypogonadism (LOH); Leydig cell

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