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Lithium chloride promotes proliferation of neural stem cells in vitro, possibly by triggering the Wnt signaling pathway

Animal Cells and Systems 2019년 23권 1호 p.32 ~ 41
Zhang Jian, He Lu, Yang Zhong, Li Lihong, Cai Wenqin,
소속 상세정보
 ( Zhang Jian ) - Chinese PLA 113rd Hospital Department of Geriatrics
 ( He Lu ) - Chinese PLA 113rd Hospital Department of Geriatrics
 ( Yang Zhong ) - Third Military Medical University Department of Neurobiology
 ( Li Lihong ) - Third Military Medical University Department of Neurobiology
 ( Cai Wenqin ) - Third Military Medical University Department of Neurobiology

Abstract


The objective of this study was to clarify the relationship between the effect and associated mechanisms of lithium chloride on neural stem cells (NSCs) and the Wnt signaling pathway. The expression of key molecules proteins related to the Wnt signaling pathway in the proliferation and differentiation of control NSCs and lithium chloride-treated NSCs was detected by Western blot analysis. Flow cytometry analysis was applied to study the cell cycle dynamics of control NSCs and NSCs treated with lithium chloride. The therapeutic concentrations of lithium chloride stimulated NSC proliferation. β-catenin expression gradually decreased, while Gsk-3β expression gradually increased (P?

키워드

Lithium chloride; Wnt signaling pathway; β-catenin; GSK-3β; neural stem cells

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