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VNN3 is a potential novel biomarker for predicting prognosis in clear cell renal cell carcinoma

Animal Cells and Systems 2019년 23권 2호 p.112 ~ 117
하미향, 정호임, 노종성, 이범구, 이동준, 한명은, 오세옥, 손동현, 김윤학,
소속 상세정보
하미향 ( Ha Mi-Hyang ) - Pusan National University School of Medicine Department of Anatomy
정호임 ( Jeong Ho-Im ) - Pusan National University School of Medicine Department of Microbiology and Immunology
노종성 ( Roh Jong-Seong ) - Pusan National University School of Medicine Department of Microbiology and Immunology
이범구 ( Lee Beom-Gu ) - Pusan National University School of Medicine Department of Microbiology and Immunology
이동준 ( Lee Dong-Jun ) - Pusan National University School of Medicine Department of Convergence Medical Science
한명은 ( Han Myoung-Eun ) - Pusan National University School of Medicine Department of Anatomy
오세옥 ( Oh Sae-Ock ) - Pusan National University School of Medicine Department of Anatomy
손동현 ( Sohn Dong-Hyun ) - Pusan National University School of Medicine Department of Microbiology and Immunology
김윤학 ( Kim Yun-Hak ) - Pusan National University School of Medicine Department of Anatomy

Abstract


Although pathological observations provide approximate prognoses, it is difficult to achieve prognosis in patients with existing prognostic factors. Therefore, it is very important to find appropriate biomarkers to achieve accurate cancer prognosis. Renal cell carcinoma (RCC) has several subtypes, the discrimination of which is crucial for proper treatment. Here, we present a novel biomarker, VNN3, which is used to prognose clear cell renal cell carcinoma (ccRCC), the most common and aggressive subtype of kidney cancer. Patient information analyzed in our study was extracted from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) cohorts. VNN3 expression was considerably higher in stages III and IV than in stages I and II. Moreover, Kaplan?Meier curves associated high VNN3 expression with poor prognoses (TCGA, p?

키워드

VNN3; biomarker; clear cell renal cell carcinoma; TCGA; ICGC

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