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Ethylparaben induces apoptotic cell death in human placenta BeWo cells via the Caspase-3 pathway

Animal Cells and Systems 2020년 24권 1호 p.34 ~ 43
김미진, 김철홍, An Mi-Jin, 이주현, Shin Geun-Seup, Song Mi-Na, 김정웅,
소속 상세정보
김미진 ( Kim Mi-Jin ) - Chung-Ang University Department of Life Science
김철홍 ( Kim Chul-Hong ) - Chung-Ang University Department of Life Science
 ( An Mi-Jin ) - Chung-Ang University Department of Life Science
이주현 ( Lee Ju-Hyun ) - Chung-Ang University Department of Life Science
 ( Shin Geun-Seup ) - Chung-Ang University Department of Life Science
 ( Song Mi-Na ) - Chung-Ang University Department of Life Science
김정웅 ( Kim Jung-Woong ) - Chung-Ang University Department of Life Science

Abstract


Parabens are generally used as preservatives in foods, pharmaceuticals, and various other commercial products. Among them, ethylparaben has weaker estrogenic characteristics than endogenous estrogen. However, growing evidence indicates that ethylparaben has an adverse effect on various human tissues. Here, we investigated whether ethylparaben induces cell death by affecting cell viability, cell proliferation, cell cycle, and apoptosis using the human placenta cell line BeWo. Ethylparaben significantly decreased cell viability in a dose-dependent manner. It caused cell cycle arrest at sub-G1 by reducing the expression of cyclin D1, whereas it decreased the cell proportion at the G0/G1 and S phases. Furthermore, we verified that ethylparaben induces apoptotic cell death by enhancing the activity of Caspase-3. Taken together, our results suggest that ethylparaben exerts cytotoxic effects in human placental BeWo cells via cell cycle arrest and apoptotic pathways.

키워드

Ethylparaben; apoptosis; cell cycle arrest; human placenta cells; BeWo

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