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SPRY4-IT1 promotes survival of colorectal cancer cells through regulating PDK1-mediated glycolysis

Animal Cells and Systems 2020년 24권 4호 p.220 ~ 227
Liu Shengyuan, Huang Feng, Ye Qing, Li Yangming, Chen Jinhu, Huang Hong,
소속 상세정보
 ( Liu Shengyuan ) - Fujian Cancer Hospital and Fujian Medical University Cancer Hospital Department of Gastroenterology
 ( Huang Feng ) - Fujian Cancer Hospital and Fujian Medical University Cancer Hospital Department of Gastroenterology
 ( Ye Qing ) - Fujian Cancer Hospital and Fujian Medical University Cancer Hospital Department of Gastroenterology
 ( Li Yangming ) - Fujian Cancer Hospital and Fujian Medical University Cancer Hospital Department of Gastroenterology
 ( Chen Jinhu ) - Fujian Cancer Hospital and Fujian Medical University Cancer Hospital Department of Gastroenterology
 ( Huang Hong ) - Fujian Cancer Hospital and Fujian Medical University Cancer Hospital Department of Gastroenterology

Abstract


Colorectal cancer (CRC) becomes the third leading cause of cancer-related deaths worldwide recently. The prognosis of CRC is still poor in decades, and targeted therapy is still a potential effective treatment. Long non-coding RNAs (lncRNAs) could regulate series of cellular functions and developmental processes. LncRNA-SPRY4-IT1 (GenBank ID AK024556) is derived from an intron of the SPRY4 gene, which was highly expressed in melanoma cells and affected the progression of multiple types of cancers. However, the mechanism of SPRY4-IT1 in CRC progression remains unclear. Herein, we found the high level of SPRY4-IT1 in human colorectal cancer (CRC) tissues and cells, and correlated with patients’ prognosis. We further noticed that SPRY4-IT1 regulated CRC cell growth and glycolysis, and promoting PDK1 expression. Our data further confirmed that SPRY4-IT1 regulated CRC progression targeting PDK1. We therefore thought SPRY4-IT1 could serve as a promising molecular target for the treatment of CRC.

키워드

SPRY4-IT1; colorectal cancer (CRC); proliferation; glycolysis; molecular target

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