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치료 위저항성 조현병: 치료 비순응을 중심으로

Pseudo-Resistant Schizophrenia: Non-Adherence to Treatment

대한조현병학회지 2020년 23권 2호 p.51 ~ 57
김혜림, 이승재,
소속 상세정보
김혜림 ( Kim Hye-Rim ) - Kyungpook National University Hospital Department of Psychiatry
이승재 ( Lee Seung-Jae ) - Kyungpook National University Hospital Department of Psychiatry

Abstract


Treatment-resistant schizophrenia (TRS) has been defined as the persistence of positive symptoms despite two or more trials of antipsychotic medication of adequate dose and duration. TRS is a serious clinical problem and occurs in approximately 30% of patients with schizophrenia. It is important that patients who do not adequately respond to antipsychotics be reevaluated to exclude or address causes other than non-responsiveness to medication, that is, the possibility of pseudo-resistance. In particular, non-adherence to oral antipsychotic treatment should be monitored to rule out pseudo-resistant cases of TRS. Moreover, patients with TRS who take their medication as required may have subtherapeutic antipsychotic plasma levels, secondary to pharmacokinetic factors. In this paper, we review the concept and exclusion of pseudo-resistance, especially owing to non-adherence or pharmacokinetic factors, and present methods to enhance drug adherence.

키워드

Adherence; Pharmacokinetics; Pseudo-resistance; Schizophrenia; Treatment-resistance

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