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Comparison of Polygenic Risk for Schizophrenia between European and Korean Populations

대한조현병학회지 2020년 23권 2호 p.65 ~ 70
이진영, 이동빈, 조은영, 백지현, 홍경수,
소속 상세정보
이진영 ( Lee Jin-Young ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Psychiatry
이동빈 ( Lee Dong-Bin ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Psychiatry
조은영 ( Cho Eun-Young ) - Samsung Biomedical Research Institute Center for Clinical Medicine
백지현 ( Baek Ji-Hyun ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Psychiatry
홍경수 ( Hong Kyung-Sue ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Psychiatry

Abstract


OBJECTIVES: This study aimed to explore whether common genetic variants that confer the risk of schizophrenia have similar effects between Korean and European ancestries using the polygenic risk score (PRS) analysis.

METHODS: Study subjects included 713 Korean patients with schizophrenia and 497 healthy controls. The Korea Biobank array was used for genotyping. Summary statistics of the most recent genome-wide association study (GWAS) of the European population were used as baseline data to calculate PRS. Logistic regression was conducted to determine the association between calculated PRS of European patients with schizophrenia and clinical diagnosis of schizophrenia in the Korean population.

RESULTS: Schizophrenia PRS was significantly higher in patients with schizophrenia than in healthy controls. The PRS at the pvalue threshold of 0.5 best explained the variance of schizophrenia (R2=0.028, p=4.4×10-6). The association was significant after adjusting for age and sex (odds ratio=1.34, 95% confidence interval=1.19-1.51, p=1.1×10?6). The pattern of the association remained similar across different p-value thresholds (0.01-1).

CONCLUSION: Schizophrenia PRS calculated using the European GWAS data showed a significant association with the clinical diagnosis of schizophrenia in the Korean population. Results suggest overlapping genetic risk variants between the two populations.

키워드

Genetic polymorphism; Genome-wide association study (GWAS); Polygenic risk score (PRS); Schizophrenia

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