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조현병 환자에서의 지연성 운동이상 발생과 세로토닌 1A 수용체유전자 rs6295 다형성과의 연관성

Association Study between Serotonin 1A Receptor Gene rs6295 Polymorphism and Tardive Dyskinesia in Patients with Schizophrenia

대한조현병학회지 2020년 23권 2호 p.71 ~ 77
이윤정, 남궁윤, 조아름, 이헌정,
소속 상세정보
이윤정 ( Lee Youn-Jung ) - Gyeongsang National University Hospital Department of Psychiatry
남궁윤 ( Namgoong Yoon ) - Korea University Guro Hospital Department of Internal Medicine
조아름 ( Cho A-Reum ) - Korea University College of Medicine Department of Psychiatry
이헌정 ( Lee Heon-Jeong ) - Korea University College of Medicine Department of Psychiatry

Abstract


OBJECTIVES: Tardive dyskinesia (TD) is a movement disorder that is characterized by hyperkinetic movements. Previous studies have suggested that the serotonergic systems are correlated with TD vulnerability. In this study, the association between a single-nucleotide polymorphism (SNP) of the serotonin 1A receptor gene (HTR1A) rs6295 and TD was investigated.

METHODS: We investigated whether HTR1A rs6295 SNP is associated with antipsychotic-induced TD in 280 Korean patients with schizophrenia. Patients with schizophrenia having TD (n=105) and those without TD (n=175) were matched for their antipsychotic exposures and other relevant variables. The HTR1A rs6295 SNP was analyzed using polymerase chain reaction (PCR)-based methods.

RESULTS: There was no significant difference in the distribution of genotypic (χ2=2.70, p=0.26) and allelic (χ2=1.87, p=0.17) frequencies between the patient groups with TD and without TD. There was no significant difference in total abnormal involuntary movement scale score (F=0.39, p=0.68) among the genotype group either.

CONCLUSION: Although there were no differences in genotypic and allelic frequency between patient groups with and without TD, further studies on association of TD with other SNPs of HTRA1 are needed to understand the pathophysiological mechanism of TD.

키워드

HTR1A; rs6295; Schizophrenia; Single-nucleotide polymorphism (SNP); Tardive dyskinesia

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