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Study of the antifungal potential of carvacrol on growth inhibition of Candida krusei in a systemic candidiasis

Oriental Pharmacy and Experimental Medicine 2020년 20권 4호 p.591 ~ 598
Feridoniy Moslem, Alizadeh Fahimeh, Kokhdan Esmaeel Panahi, Khodavandi Alireza,
소속 상세정보
 ( Feridoniy Moslem ) - Islamic Azad University Yasooj Branch Department of Microbiology
 ( Alizadeh Fahimeh ) - Islamic Azad University Yasooj Branch Department of Microbiology
 ( Kokhdan Esmaeel Panahi ) - Yasuj University of Medical Sciences Medicinal Plants Research Center
 ( Khodavandi Alireza ) - Islamic Azad University Gachsaran Branch Department of Biology

Abstract


Candidiasis caused by non-albicans Candida species present a serious global health threat. Although the available antifungal drugs are recommended, resistance phenomenon of these agents is beginning to emerge, demonstrating the urgently need for new and effective antifungal agents. Here, we have aimed to describe the antifungal activity of carvacrol against Candida krusei both in vitro and in a systemic candidiasis mouse model. In vitro susceptibility of C. krusei isolates to carvacrol were assessed using the Clinical and Laboratory Standards Institute broth microdilution reference method. In vivo, carvacrol was evaluated in murine models of systemic candidiasis by determination of fungal loads of kidneys, survival time and histopathologic analyses. Carvacrol exhibit minimum inhibitory concentration in the 6.00?±?2.80 μg/mL to 8.00?±?0.00 μg/mL range. In vivo, carvacrol decreased fungal load of kidneys (p?

키워드

Animal models; Candida; Candidiasis; Fluconazole; In vitro

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