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A Comprehensive Study of SARS-CoV-2:From 2019-nCoV to COVID-19 Outbreak

Microbiology and Biotechnology Letters 2020년 48권 3호 p.252 ~ 266
Waris Abdul, Ali Muhammad, Khan Atta Ullah, Ali Asmat, Baset Abdul,
소속 상세정보
 ( Waris Abdul ) - Quaid-i-Azam University Department of Biotechnology
 ( Ali Muhammad ) - Quaid-i-Azam University Department of Biotechnology
 ( Khan Atta Ullah ) - University of Malakand Chakdara Department of Biotechnology
 ( Ali Asmat ) - Hazara University Mansehra Centre for Human Genetics
 ( Baset Abdul ) - Bacha Khan University Charsadda Department of Zoology

Abstract


The coronavirus disease 2019 (COVID-19) is a highly contagious pneumonia that has spread throughout the world. It is caused by a novel, single stranded RNA virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Genetic analysis revealed that, phylogenetically, the SARS-CoV-2 is related to severe acute respiratory syndrome-like viruses seen in bats. Because of this, bats are considered as a possible primary reservoir. The World Health Organization has declared the COVID-19 outbreak as a pandemic. As of May 27, 2020, more than 5,406,282 confirmed cases, and 343,562 confirmed deaths have been reported worldwide. Currently, there are no approved vaccines or antiviral drugs available against COVID-19. Newly developed vaccines are in the first stage of clinical trials, and it may take a few months to a few years for their commercialization. At present, remdesivir and chloroquine are the promising drugs for treating COVID-19 patients. In this review, we summarize the diversity, genetic variations, primary reservoirs, epidemiology, clinical manifestations, pathogenesis, diagnosis, treatment strategies, and future prospects with respect to controlling the spread of COVID-19.

키워드

Coronavirus; 2019-nCoV; COVID-19 outbreak; SARS-CoV-2; diversity; epidemiology

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