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Identification of a Prophage-encoded Abortive Infection System in Levilactobacillus brevis

Microbiology and Biotechnology Letters 2020년 48권 3호 p.322 ~ 327
Feyereisen Marine, Mahony Jennifer, O’Sullivan Tadhg, Boer Viktor, van Sinderen Douwe,
소속 상세정보
 ( Feyereisen Marine ) - University College Cork School of Microbiology
 ( Mahony Jennifer ) - University College Cork School of Microbiology
 ( O’Sullivan Tadhg ) - Heineken Supply Chain B.V. HEINEKEN Global Innovation and Research
 ( Boer Viktor ) - Heineken Supply Chain B.V. HEINEKEN Global Innovation and Research
 ( van Sinderen Douwe ) - University College Cork School of Microbiology

Abstract


Abortive infection systems (Abi) are phage resistance systems that can be prophage-encoded. Here, two genes encoding an Abi system were identified on a prophage sequence contained by the chromosome of the Levilactobacillus brevis strain UCCLBBS124. This Abi system is similar to the two-component AbiL system encoded by Lactococcus lactis biovar. diacetylactis LD10-1. The UCCLBBS124 prophage-derived Abi system (designated here as AbiL124) was shown to exhibit specific activity against phages infecting L. brevis and L. lactis strains. Expression of the AbiL124 system was shown to cause reduction in the efficiency of plaquing and cell lysis delay for phages of both species.

키워드

Abi system; bacteriophage; lactic acid bacteria; beer spoilage

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