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코끼리마늘의 3T3-L1 지방세포 분화억제 효과

Elephant Garlic Extracts Inhibit Adipogenesis in 3T3-L1 Adipocytes

Microbiology and Biotechnology Letters 2020년 48권 3호 p.383 ~ 388
이슬기, Hahn Dong-Yup, 김수린, 이원영, 남주옥,
소속 상세정보
이슬기 ( Lee Seul-Gi ) - Kyungpook National University Department of Food Science and Biotechnology
 ( Hahn Dong-Yup ) - Kyungpook National University Department of Food Science and Biotechnology
김수린 ( Kim Soo-Rin ) - Kyungpook National University Department of Food Science and Biotechnology
이원영 ( Lee Won-Young ) - Kyungpook National University Department of Food Science and Biotechnology
남주옥 ( Nam Ju-Ock ) - Kyungpook National University Department of Food Science and Biotechnology

Abstract


Elephant garlic (Allium ampeloprasum L.) has been reported to have several pharmacological effects. However, its anti-adipogenic effect and the possible molecular mechanisms have not yet been reported. In this study, we demonstrate that elephant garlic extracts suppress adipogenesis in 3T3-L1 adipocytes. Raw and steamed elephant garlic extracts (REG and SEG, respectively) suppressed the differentiation of adipocytes and cellular lipid accumulation. Of note, the anti-differentiation effect of REG treatment on 3T3-L1 cells resulted in cytotoxicity, whereas SEG-treated cells displayed no such cytotoxicity. Additionally, SEG treatment significantly reduced the adipogenesis-related gene expression of PPAR γ, C/EBPα, adiponectin, Ap2, and LPL. To our knowledge, these results are the first evidence of the anti-adipogenic effects of elephant garlic extracts on 3T3-L1 adipocytes.

키워드

3T3-L1 adipocytes; Allium ampeloprasum L; anti-adipogenic; elephant garlic; steamed elephant garlic

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