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Tumor associated mast cells: biological roles and therapeutic applications

Anatomy & Cell Biology 2020년 53권 3호 p.245 ~ 251
Saxena Shikha, Singh Anil, Singh Priyanka,
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 ( Saxena Shikha ) - RUHS College of Dental Sciences Department of Oral Pathology
 ( Singh Anil ) - Saraswati Dental College and Hospital Department of Oral Pathology
 ( Singh Priyanka ) - King George Medical University Faculty of Dental Sciences Department of Oral Pathology

Abstract


Mast cells (MCs) are immune cells of the myeloid lineage and are present in connective tissues throughout the body. The activation and degranulation of MCs significantly modulates many aspects of physiological and pathological conditions in various settings. Recent data have expanded the concept that inflammation is a critical component for tumor progression. Interestingly, three of the most aggressive human cancers, malignant melanoma, breast carcinoma and colorectal adenocarcinoma, are commonly associated with a marked host response comprising of various inflammatory cells, but especially MCs around the tumor periphery. A systematic review of the literature was performed based on the English titles listed in the PubMed, EBSCO, Cochrane, Science Direct, ISI web Science, and SciELO databases using the keywords. Abstracts and full-text articles were assessed. This review summarizes the current understanding of the role of MCs in tumor progression.

키워드

Mast cell activation; Development; Proliferation; Migration; Survival

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