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Serum adipocytokines and adiposity as predictive indices of preeclampsia

Clinical Hypertension 2020년 26권 1호 p.19 ~ 19
Bawah Ahmed Tijani, Yeboah Francis Agyemang, Nanga Salifu, Alidu Huseini, Ngala Robert A.,
소속 상세정보
 ( Bawah Ahmed Tijani ) - University of Health and Allied Health Sciences School of Allied Health Sciences Department of Medical Laboratory Science
 ( Yeboah Francis Agyemang ) - Kwame Nkrumah University Science and Technology Department of Molecular Medicine
 ( Nanga Salifu ) - University of Health and Allied Sciences School of Basic and Biomedical Science
 ( Alidu Huseini ) - University of Health and Allied Health Sciences School of Allied Health Sciences Department of Medical Laboratory Science
 ( Ngala Robert A. ) - Kwame Nkrumah University Science and Technology Department of Molecular Medicine

Abstract


Background: This study was aimed at determining the levels of serum adiponectin, leptin, resistin, visfatin and lipids during the first trimester in pregnant women and to evaluate the relationship between these biochemical markers and preeclampsia (PE). Available evidence point to changes in the levels of these adipokines in PE hence this study examined the potential of using these biomarkers in the prediction of the disease.

Methods: This was a case-control study which compared first trimester serum biochemical and anthropometric parameters in pregnant women who subsequently developed PE and those who did not. Blood pressure and urine protein were determined after 20?weeks of gestation and diagnosis of PE performed according to the guidelines of the American Heart Association.

Results: There was no significant difference (p?>?0.05) in the lipid profile with the exception of HDL cholesterol which was significantly lower (p?=?0.043) in the PE group compared to the normotensive group. There were, however, significant differences (p?
Conclusion: Adiponectin, leptin, resistin and visfatin were found to be significant predictors of PE, with resistin being the best predictor after controlling for BMI. However, adiponectin was the best predictor after controlling for BMI, age, parity and family history of diabetes and preeclmapsia.

키워드

Preeclampsia; Adiponectin; Leptin; Resistin; Visfatin

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