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비인강암 환자에서 Cisplatin과 방사선 병합치료시 발생하는 감각신경성 청력손실

Sensory Neural Hearing Loss after Concurrent Cisplatin and Radiation Therapy for Nasopharyngeal Carcinoma

대한두경부종양학회지 1998년 14권 1호 p.15 ~ 19
소속 상세정보
오영택/Young Tark Oh 강승희/전미선/고중화/최진혁/Seung Hee Kang/Mison Chun/Joong Hwa Koh/Jin Hyuk Choi

Abstract

결 론
비인강암 환자에서 방사선치료와 cisplatin 약물치료를 동시에 병합하여 치료하는 경우 감
각신경성 난청의 발생률이 75%로 높았으나. 추적관찰 기간이 짧고, 상대적으로 적은 수의
환자를 대상으로 하였기 때문에 향후 지속적인 연구가 요망된다. 그러나 방사선치료와
Cisplatin을 병합하여 치료할 경우. 특히 동시에 병합할 경우에는 감각신경성 난청이 발생할
가능성이 증가하므로. 내이에 조사되는 방사선량과 cisplatin의 총 음량을 적절히 조절하여야
하며, 치료 후에는 증상을 호소하지 않더라도 주기적인 청각검사를 시행하여 감각신경성 난
청의 발생여부를 추적하여야 할 것이다.

Objectives : It is expected that the combined cisplatin and radiation therapy far
nasopharyngeal carcinoma produces more sensory neural hearing losses compared to
radiation therapy alone. The purpose of this study was to evaluate the incidence of
sensory neural hearing losses after concurrent cisplatin and radiation therapy for
nasopharyngeal carcinoma.
Materials and Methods : From fun. 1994 to Mar 1997, 10 patients were available for
this study with the 1311owing eligibility criteria : 1) The patients received concurrent
cisplatin and radiation therapy for nasopharyngeal carcinoma. 2) There was no
pre-existing auditory disease except serous otitis media due to nasopharyngeal
carcinoma. 3) They had normal sensorineural hearing function on the pretreatment pure
tone audiogram. 4) Pure tone audiograms were performed at least one time artier
treatment betiveen 6months to 1 year follow-up without local recurrence.
Results : At 1 year 1311ow-up, 3 patients complained of decreased hearing capacity.
Sensorineural hearing losses were developed in 15 ears out of 20(75%) and were more
frequent and severe in high frequency area on pure tone audiogram.
Conclusion : The concurrent cisplatin and radiation therapy for nasopharyngeal
carcinoma may produce sensorineural hearing losses more frequently compared to
historical data of radiation therapy alone and close evaluations with regular audiograms
are necessary even in patients symptoms without symptoms and signs of hearing
impairment.

키워드

Sensorineural hearing loss; Radiation therapy; Cisplatin; Nasopharyngeal carcinoma;

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