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ICR 마우스에서 방사선 용량에 따른 혈액변화의 관찰

Effects of whole-body gamma-irradiation on the peripheral blood of ICR mouse

대한수의학회지 2002년 42권 2호 p.183 ~ 190
김성호 (  ) - 전남대학교 수의과대학

이종환 (  ) - 전남대학교 수의과대학
김세라 (  ) - 전남대학교 수의과대학
이해준 (  ) - 전남대학교 수의과대학
이윤실 (  ) - 한국원자력병원
김태환 (  ) - 한국원자력병원
류시윤 (  ) - 충남대학교 수의과대학

Abstract


The effects of ionizing radiation on the peripheral blood elements of ICR mouse were examined after varying doses of whole-body gamma-irradiation. ICR mice (n=50) were exposed to 0, 2, 4, 6 and 8 Gy gamma-ray (^60Co) at 10 Gy/min. The animals were studied for their hematological response on days, 3, 7, 14, 21, 42 and 56 post irradiation. No significant change was noted in erythrocyte, hemoglobin and hematocrit values after irradiation with dose of 2 Gy. Decreasing erythrocyte, hemoglobin and hematocrit values occured after irradiation with doses of more than 4 Gy on day 7 after irradiation followed by a sharp fall on day 14. A recovery in these values was noted after 3 weeks of irradiation. Thrombocyte counts decreased on day 3, reaching minimal values on day 7. The total number of leukocytes was reduced on day 3, mainly because of a decrease in the lymphocyte population. An evident lymphopenia and neutropenia occur almost on the day 3 and last up to the day 28 after irradiation. All of the hematological values decreased in the blood in a dose-dependent manner at the same time.

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