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정상 및 허혈 / 재관류 흰쥐 심장에 대한 2-클로로-3- ( 4-시아노페닐아미노 ) -1 , 4-나프토퀴논 ( NQ-Y15 ) 의 작용

Effects of 2-Chloro-3- ( 4-cyanophenylamino ) -1 , 4-naphthoquinone ( NQ-Y15 ) on Normal and Ischemical / Reperfused Rat Hearts

약학회지 1997년 41권 6호 p.829 ~ 836
소속 상세정보
문창현/Moon CH 김지영/백은주/이수환/류충규/Kim JY/Baik EJ/Lee SH/Ryu CK

Abstract


Studies on the effect of quinones on cardiac function has been conducted with normal hearts. But not with injured hearts, I.e. ischemia/reperfusion-injured heart. Quinone compounds are known to produce oxygen free radicals during metabolism, and for this reason, quinones are implicated in the aggravation of ischemia/reperfusion injury or cardioprotection, as in the case of ischemic preconditioning depending on the experimental conditions. The present study was carried out to examine the effect of 2-chloro-3-(4-cyanophenylamino)-1.4-naphthoquinone (NQ-Y15) on cardiac function of ischemic/reperfused and normal rat hearts. In isolated perfused hearts, various functional parameters such as left ventricular developed pressure (LVDP), left ventricular end-diastolic pressure (EDP) and maximum positive and negative dP/dt (+/-dP/dtmax), time to contracture, heart rate (HR) and coronary flow rate (CFR) were measured before and 30 min after dosing and following 25 min ischemia/30min reperfusion. NQ-Y15 increased LVDP, +dP/dtmax and -dP/dtmin by 18%. 30%, and 40%, respectively. There were no significant changes in other haemodynamic parameters. After ischemia/reperfusion injury, pretreatment with NQ-Y15 induced a significant decrease in LVDP and +/-dP/dtmax, but an increase in EDP. LDH-release was not significantly increased. These results suggested that NQ-Y15 may augment the ventricular contractility but it makes hearts more vulnerable to ischemia/reperfusion injury.

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