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Regulatory roles of G-protein coupled receptors in adipose tissue metabolism and their therapeutic potential

Archives of Pharmacal Research 2021년 44권 2호 p.133 ~ 145
임현영, 박지현, 임서우, 한주형, 김경민, 이윤희,
소속 상세정보
임현영 ( Im Hyeon-Yeong ) - Seoul National University College of Pharmacy
박지현 ( Park Ji-Hyun ) - Seoul National University College of Pharmacy
임서우 ( Im Seo-Woo ) - Seoul National University College of Pharmacy
한주형 ( Han Ju-Hyeong ) - Seoul National University College of Pharmacy
김경민 ( Kim Kyung-Min ) - Seoul National University College of Pharmacy
이윤희 ( Lee Yun-Hee ) - Seoul National University College of Pharmacy

Abstract


The high incidence of obesity has increased the need to discover new therapeutic targets to combat obesity and obesity-related metabolic diseases. Obesity is defined as an abnormal accumulation of adipose tissue, which is one of the major metabolic organs that regulate energy homeostasis. However, there are currently no approved anti-obesity therapeutics that directly target adipose tissue metabolism. With recent advances in the understanding of adipose tissue biology, molecular mechanisms involved in brown adipose tissue expansion and metabolic activation have been investigated as potential therapeutic targets to increase energy expenditure. This review focuses on G-protein coupled receptors (GPCRs) as they are the most successful class of druggable targets in human diseases and have an important role in regulating adipose tissue metabolism. We summarize recent findings on the major GPCR classes that regulate thermogenesis and mitochondrial metabolism in adipose tissue. Improved understanding of GPCR signaling pathways that regulate these processes could facilitate the development of novel pharmacological approaches to treat obesity and related metabolic disorders.

키워드

GPCR; Obesity; Adipose tissue; Adrenoceptor; Adenosine receptor; Frizzled receptor; Lysophospholipid receptor

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