잠시만 기다려 주세요. 로딩중입니다.

Mouse model of the adipose organ: the heterogeneous anatomical characteristics

Archives of Pharmacal Research 2021년 44권 9호 p.857 ~ 875
전광훈,
소속 상세정보
전광훈 ( Chun Kwang-Hoon ) - Gachon University College of Pharmacy

Abstract


Adipose tissue plays a pivotal role in energy storage, hormone secretion, and temperature control. Mammalian adipose tissue is largely divided into white adipose tissue and brown adipose tissue, although recent studies have discovered the existence of beige adipocytes. Adipose tissues are widespread over the whole body and each location shows distinctive metabolic features. Mice are used as a representative experimental model system in metabolic studies due to their numerous advantages. Importantly, the adipose tissues of experimental animals and humans are not perfectly matched, and each adipose tissue exhibits both similar and specific characteristics. Nevertheless, the diversity and characteristics of mouse adipose tissue have not yet been comprehensively summarized. This review summarizes diverse information about the different types of adipose tissue being studied in mouse models. The types and characteristics of adipocytes were described, and each adipose tissue was classified by type, and features such as its distribution, origin, differences from humans, and metabolic characteristics were described. In particular, the distribution of widely studied adipose tissues was illustrated so that researchers can comprehensively grasp its location. Also, the adipose tissues misused or confusingly used among researchers were described. This review will provide researchers with comprehensive information and cautions needed to study adipose tissues in mouse models.

키워드

White adipose tissue; Brown adipose tissue; Beige adipose tissue; Adipose organ; Visceral; Subcutaneous; Mice model

원문 및 링크아웃 정보

등재저널 정보