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Vaccine-related Anaphylaxis Cases Confirmed by KCDC from 2001?2016

Journal of Korean Medical Science 2020년 35권 38호 p.337 ~ 337
Roh Eui-Jeong, 이미희, 송근백, 이연경, 김민경, 김태은, 정은희,
소속 상세정보
 ( Roh Eui-Jeong ) - Sun General Hospital Department of Pediatrics
이미희 ( Lee Mi-Hee ) - Incheon Medical Center Department of Pediatrics
송근백 ( Song Kun-Baek ) - Chungnam National University School of Medicine Department of Pediatrics
이연경 ( Lee Yeon-Kyeong ) - Korea Centers for Disease Control and Prevention
김민경 ( Kim Min-Kyung ) - Korea Centers for Disease Control and Prevention
김태은 ( Kim Tae-Eun ) - Korea Centers for Disease Control and Prevention
정은희 ( Chung Eun-Hee ) - Chungnam National University School of Medicine Department of Pediatrics

Abstract


Background: A national immunization program (NIP) to prevent disease and reduce mortality from vaccine preventable diseases (VPD) is very important.

Methods: We analyzed only the anaphylaxis cases that occurred between 2001 and 2016 that Korea Centers for Disease Control and Prevention (KCDC) determined had a definite causal relationship with a vaccine. The clinical symptoms were assessed according to the Brighton Collaboration case definition (BCCD) level.

Results: During the period, there were 13 cases of vaccine-related anaphylaxis. The median age was 9 years (range, 1 month to 59 years). The incidence of anaphylaxis per million doses was 0.090 in 2005, 0.079 in 2012, 0.071 in 2013, 0.188 in 2015, and 0.036 in 2016. Of those cases, 23.1% were influenza vaccines, and 76.9% were BCCD level 2. Epinephrine was used in 46.2%.

Conclusion: Vaccine-related anaphylaxis seems to have been very rare in the past, but health care professionals must always be aware of anaphylaxis.

키워드

Vaccine; Anaphylaxis; Adverse Reaction; Vaccine Preventable Diseases

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