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Renal Syndromic Hearing Loss Is Common in Childhood-onset Chronic Kidney Disease

Journal of Korean Medical Science 2020년 35권 44호 p.364 ~ 364
김지현, 이동한, Lee Bong-Jin, 임선희, 안요한, 강희경, 하일수, 정해일,
소속 상세정보
김지현 ( Kim Ji-Hyun ) - Seoul National University Bundang Hospital Department of Pediatrics
이동한 ( Lee Dong-Han ) - Konkuk University School of Medicine Konkuk University Medical Center Department of Otorhinolaryngology-Head and Neck Surgery
 ( Lee Bong-Jin ) - Seoul National University Hospital Department of Emergency Medicine
임선희 ( Lim Seon-Hee ) - Seoul National University Children’s Hospital Department of Pediatrics
안요한 ( Ahn Yo-Han ) - Seoul National University College of Medicine Department of Pediatrics
강희경 ( Kang Hee-Gyung ) - Seoul National University College of Medicine Department of Pediatrics
하일수 ( Ha Il-Soo ) - Seoul National University College of Medicine Department of Pediatrics
정해일 ( Cheong Hae-Il ) - Seoul National University College of Medicine Department of Pediatrics

Abstract


Background: Hearing loss (HL) in children may adversely affect their development. HL is more prevalent in patients with chronic kidney disease (CKD) than in the general population. This study evaluated the prevalence of HL and its underlying diseases in patients with childhood-onset in CKD.

Methods: In this retrospective study of a tertiary referral center, childhood-onset CKD patients (stage 2?5, age at onset of renal symptom < 18 years) were recruited. We referred to the “renal” syndromic HL as cases with genetic or syndromic diseases, or extra-renal anomalies in addition to HL and CKD.

Results: A total of 421 patients (male:female = 279:142) were reviewed according to the causes of CKD: congenital anomalies of the kidney and urinary tract (CAKUT; n = 184, 43.7%), glomerulopathies (GP; n = 105, 24.9%), cystic kidney diseases (CYST; n = 39, 9.3%), perinatal problems (PP; n = 29, 6.9%), and others (n = 64, 15.2%). HL was detected in 82 (19.5%) patients, including 51 (12.1%) patients with sensorineural hearing loss (SNHL), 30 (7.1%) with conductive hearing loss (CHL), and 1 patient with mixed HL. The prevalence of HL in each group was as follows: 16.8% in the CAKUT group, 28.6% in the GP group, 12.8% in the CYST group, 24.1% in the PP group, and 14.1% in the others group. HL was more common in higher CKD stages, especially CHL in end-stage renal disease. SNHL was more prevalent in CKD from GP. Of the 82 patients with HL, 50% had renal syndromic HL: 58.8% of SNHL and one-third of CHL were renal syndromic HL.

Conclusion: One-fifth of the childhood-onset CKD had HL. Collectively, renal syndromic HL comprised half of the HL in this study. To improve the quality of life in patients with childhood-onset CKD, we suggest that HL should be considered, requiring surveillance, and if necessary, early intervention.

키워드

Hearing Loss; Chronic Kidney Disease; Children; Syndromic Hearing Loss

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