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The Impact of Erosive Reflux Esophagitis on the Decline of Lung Function in the General Population

Journal of Korean Medical Science 2021년 36권 5호 p.29 ~ 29
Kang Hye-Rin, 이예진, 이하연, 박태연, 이중규, 허은영, 정희순, 최승호, 김덕겸,
소속 상세정보
 ( Kang Hye-Rin ) - Seoul National University College of Medicine Department of Internal Medicine
이예진 ( Lee Ye-Jin ) - Kangdong Sacred Heart Hospital Department of Internal Medicine
이하연 ( Lee Ha-Youn ) - Serim General Hospital Department of Internal Medicine
박태연 ( Park Tae-Yun ) - Seoul Metropolitan Government-Seoul National University Boramae Medical Center Department of Internal Medicine
이중규 ( Lee Jung-Kyu ) - Seoul Metropolitan Government-Seoul National University Boramae Medical Center Department of Internal Medicine
허은영 ( Heo Eun-Young ) - Seoul National University College of Medicine Department of Internal Medicine
정희순 ( Chung Hee-Soon ) - Seoul National University College of Medicine Department of Internal Medicine
최승호 ( Choi Seung-Ho ) - Seoul National University Hospital Healthcare System Gangnam Center Department of Internal Medicine
김덕겸 ( Kim Deog-Kyeom ) - Seoul National University College of Medicine Department of Internal Medicine

Abstract


Background: The impact of reflux esophagitis on the decline of lung function has been rarely reported. This study was performed to evaluate the association between erosive reflux esophagitis and lung function changes.

Methods: We included patients with normal lung function who underwent esophagogastroduodenoscopy for health screening from a health screening center. Patients with persistent erosive reflux esophagitis on two discrete endoscopic examinations were designated as the erosive reflux esophagitis group. We also selected patients without erosive reflux esophagitis and matched them 1:4 with patients from the erosive reflux esophagitis group. We estimated annual forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) changes from baseline and compared these estimates by the linear mixed regression model. We also estimated the biannual incidence of chronic obstructive pulmonary disease (COPD).

Results: In total, 1,050 patients (210 patients with erosive reflux esophagitis, and 840 matched controls) were included. The median follow-up duration for spirometry was six years. In patients with erosive reflux esophagitis, mild reflux esophagitis (A grade) was most common (165 patients, 78.6%). The adjusted annual FEV1 change in patients with erosive reflux esophagitis was ?51.8 mL/yr, while it decreased by 46.8 mL/yr in controls (P = 0.270). The adjusted annual FVC decline was similar between the two groups (?55.8 vs. ?50.5 mL/yr, P = 0.215). The estimated COPD incidence during the follow-up period was not different between the erosive reflux esophagitis and control groups.

Conclusion: In patients with normal lung function, the presence of erosive reflux esophagitis did not affect the annual declines in FEV1 or FVC.

키워드

Gastroesophageal Reflux; Respiratory Function Tests; Forced Expiratory Volume; Vital Capacity; Pulmonary Disease, Chronic Obstructive; Community Health Services

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